The main issue in osteoarthritis in horses is the degradation of articular cartilage and the cartilage matrix. Current treatment methods focus on managing symptoms with non-steroidal anti-inflammatory drugs (NSAIDs) or steroids, which do not address the underlying causes of OA and can have negative side effects.
In the search for a disease-modifying treatment, scientists have turned their attention to the endocannabinoid system (ECS), which plays a role in maintaining joint health. Studies have identified the presence of cannabinoid receptors in joint tissues, sparking interest in cannabinoids as potential medications for OA.
Cannabigerol (CBG), a lesser-known cannabinoid, has emerged as a promising candidate. It has shown potential not only in alleviating symptoms but also in modifying the course of the disease by stopping joint degeneration and promoting the rebuilding of damaged cartilage.
A study conducted by Reyad Elbarbary and Fadia Kamal at Penn State College of Medicine, using mouse models, compared the effects of CBD and CBG on OA. It found that CBD along with CBG significantly reduced the thickness of the synovial membrane, suggesting strong anti-inflammatory properties. CBG alleviated cartilage degradation, which was not observed with CBD alone. CBG also preserved the number of chondrocytes, the cells responsible for maintaining the cartilage matrix, indicating its potential for cartilage protection and regeneration.
The study also highlighted CBG's role as an agonist of the CB2 receptor, which helps prevent cartilage degradation and promotes the production of aggrecan (ACAN-proteoglycan 1 chondroitin sulfate), a key component of the cartilage matrix.
Although the study used cannabis extracts and not pure cannabinoids, suggesting the possibility of an entourage effect, the results underscore the therapeutic potential of CBG in treating both the symptoms and underlying causes of OA.
Further Research and Considerations
Despite promising results, further research is needed to fully understand the therapeutic potential of CBG and develop it as a viable treatment option for equine osteoarthritis. The current findings provide a foundation for future studies and are a source of hope for a disease-modifying treatment for this debilitating condition.
Note for Blog Readers:
The information presented is based on scientific research and should be considered as part of ongoing studies in the field of veterinary medicine. Horse owners and veterinarians should consult with professionals before considering any new treatment methods.
If you are looking for a product rich in both CBD and CBG, we recommend the Hempqualizer preparations, which you can learn more about here.
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